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- 姓名：劉志華
- 職務(wù)：
- 職稱(chēng)：副教授/碩導(dǎo)
- 所屬系：食品生物技術(shù)系
- 郵箱：liuzhihua@hfut.edu.cn
- 辦公地點(diǎn)：食生樓1106

個(gè)人簡(jiǎn)介
研究領(lǐng)域
科研項(xiàng)目
學(xué)術(shù)成果
榮譽(yù)獎(jiǎng)項(xiàng)

2025.01-至今合肥工業(yè)大學(xué) 副教授

2021.08-2024.12合肥工業(yè)大學(xué) 講師

2019.01-2021.07合肥工業(yè)大學(xué) 博士后

2015.09-2018.12合肥工業(yè)大學(xué) 博士

2012.09-2015.09合肥工業(yè)大學(xué) 碩士

1.食品營(yíng)養(yǎng)與安全：食品中重金屬及新污染物的神經(jīng)毒性機(jī)制與膳食干預(yù)改善策略
2.神經(jīng)退行性疾病：發(fā)病機(jī)制、早期預(yù)警標(biāo)志物及營(yíng)養(yǎng)調(diào)控干預(yù)研究
3.衰老機(jī)制及抗衰老功能成分挖掘：基于氧化應(yīng)激 / 細(xì)胞衰老通路的機(jī)制解析與抗衰老功能物質(zhì)挖掘

1.國(guó)家自然科學(xué)基金青年基金，保幼激素通過(guò)Tsf1調(diào)控果蠅鐵剝奪的機(jī)制研究, 2022.01- 2024.12，主持
2.國(guó)家重點(diǎn)研發(fā)子課題，動(dòng)物源新食物資源中過(guò)敏原精準(zhǔn)化脫除技術(shù)研究，2023.12-2027.12，主持
3.茶樹(shù)生物學(xué)與資源利用國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題：EGCG通過(guò)抑制鐵死亡改善帕金森病的機(jī)制研究, 2021.10-2023.09，主持
4.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計(jì)劃B，JNK信號(hào)通路在鉛致腸道損傷中的作用機(jī)制研究，2022.04-2023.12，主持
5.青年教師科研創(chuàng)新啟動(dòng)專(zhuān)項(xiàng)A項(xiàng)目，鉛暴露影響果蠅生長(zhǎng)發(fā)育的機(jī)制研究，2022.05-2024.05，主持
6.青年教師科研創(chuàng)新啟動(dòng)專(zhuān)項(xiàng)B項(xiàng)目，果蠅保幼激素通過(guò)轉(zhuǎn)鐵蛋白Tsf1調(diào)控生殖的機(jī)制研究，2020.05-2022.04，主持

代表性論文
1. Z.H. Liu #, S. Ai#, Y. Xia, and H.L. Wang*, Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies. Sci Total Environ, 2024. 931: p. 172781.
2. Z.H. Liu#, Y. Xia#, S. Ai, and H.L. Wang, Health risks of Bisphenol-A exposure: From Wnt signaling perspective. Environ Res, 2024. 251(Pt 2): p. 118752.
3. Z.H. Liu*, Y. Zhai, Y. Xia, and Q. Liao, Mating modifies oxidative stress in the brain and confers protection against Parkinson's Disease in a Drosophila model. Biochem Biophys Res Commun, 2024. 737: p. 150911.
4. Z.H. Liu*, Yuyin Zhai, Jiakai Zhang, Wei Huang, Wanrong Li, Wenting Qin, Mitochondrial iron deficiency mediated inhibition of ecdysone synthesis underlies lead (Pb) induced developmental toxicity in Drosophila melanogaster. Toxicol Appl Pharmaco, 2025, 497: 117283
5. Z.H. Liu #; Jin Shang#; Lailai Yan; Tian Wei; Ling Xiang; Hui-Li Wang*; Jigui Cheng; Guiran Xiao*. Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster. Chemosphere, 2020, 243: 125428.
6. Ye, Y.Y., Z.H. Liu*, and H.L. Wang*, Fat body derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster. FASEB J, 2024. 38(14): p. e23805.
7. Xia, Y., H. Wang, Z. Xie, Z.H. Liu*, and H.L. Wang*, Inhibition of ferroptosis underlies EGCG mediated protection against Parkinson's disease in a Drosophila model. Free Radic Biol Med, 2024. 211: p. 63-76.
8. Li, D., S. Ai, C. Huang, Z.H. Liu*, and H.L. Wang*, Icariin rescues developmental BPA exposure induced spatial memory deficits in rats. Toxicol Appl Pharmacol, 2024. 482: p. 116776.
9. Guiran Xiao#*, Z.H. Liu#, Mengran Zhao, Hui-Li Wang*, Bing Zhou*. Transferrin 1 traffics iron from the gut and antagonizes the action of ferritin in Drosophila melanogaster. Cell Reports, 2019, 26(3): 748-758.

2022及2023年青年教師教學(xué)基本功比賽院級(jí)二等獎(jiǎng)
2024年青年教師教學(xué)基本功比賽院級(jí)一等獎(jiǎng)
2023年全國(guó)青年教師毒理學(xué)教學(xué)競(jìng)賽二等獎(jiǎng)
2024年指導(dǎo)本科生獲全國(guó)大學(xué)生生命科學(xué)競(jìng)賽國(guó)家級(jí)三等獎(jiǎng)、省級(jí)二等獎(jiǎng)

職務(wù)：		職稱(chēng)：	副教授/碩導(dǎo)
所屬系：	食品生物技術(shù)系	郵箱：	liuzhihua@hfut.edu.cn
辦公地點(diǎn)：	食生樓1106	學(xué)術(shù)成果	<br>代表性論文 <br>1. Z.H. Liu #, S. Ai#, Y. Xia, and H.L. Wang, Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies. Sci Total Environ, 2024. 931: p. 172781. <br>2. Z.H. Liu#, Y. Xia#, S. Ai, and H.L. Wang, Health risks of Bisphenol-A exposure: From Wnt signaling perspective. Environ Res, 2024. 251(Pt 2): p. 118752. <br>3. Z.H. Liu, Y. Zhai, Y. Xia, and Q. Liao, Mating modifies oxidative stress in the brain and confers protection against Parkinson's Disease in a Drosophila model. Biochem Biophys Res Commun, 2024. 737: p. 150911. <br>4. Z.H. Liu, Yuyin Zhai, Jiakai Zhang, Wei Huang, Wanrong Li, Wenting Qin, Mitochondrial iron deficiency mediated inhibition of ecdysone synthesis underlies lead (Pb) induced developmental toxicity in Drosophila melanogaster. Toxicol Appl Pharmaco, 2025, 497: 117283 <br>5. Z.H. Liu #; Jin Shang#; Lailai Yan; Tian Wei; Ling Xiang; Hui-Li Wang; Jigui Cheng; Guiran Xiao. Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster. Chemosphere, 2020, 243: 125428. <br>6. Ye, Y.Y., Z.H. Liu, and H.L. Wang, Fat body derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster. FASEB J, 2024. 38(14): p. e23805. <br>7. Xia, Y., H. Wang, Z. Xie, Z.H. Liu, and H.L. Wang, Inhibition of ferroptosis underlies EGCG mediated protection against Parkinson's disease in a Drosophila model. Free Radic Biol Med, 2024. 211: p. 63-76. <br>8. Li, D., S. Ai, C. Huang, Z.H. Liu, and H.L. Wang, Icariin rescues developmental BPA exposure induced spatial memory deficits in rats. Toxicol Appl Pharmacol, 2024. 482: p. 116776. <br>9. Guiran Xiao#, Z.H. Liu#, Mengran Zhao, Hui-Li Wang, Bing Zhou. Transferrin 1 traffics iron from the gut and antagonizes the action of ferritin in Drosophila melanogaster. Cell Reports, 2019, 26(3): 748-758.
研究領(lǐng)域	<br>1.食品營(yíng)養(yǎng)與安全：食品中重金屬及新污染物的神經(jīng)毒性機(jī)制與膳食干預(yù)改善策略 <br>2.神經(jīng)退行性疾病：發(fā)病機(jī)制、早期預(yù)警標(biāo)志物及營(yíng)養(yǎng)調(diào)控干預(yù)研究 <br>3.衰老機(jī)制及抗衰老功能成分挖掘：基于氧化應(yīng)激 / 細(xì)胞衰老通路的機(jī)制解析與抗衰老功能物質(zhì)挖掘	科研項(xiàng)目	<br>1.國(guó)家自然科學(xué)基金青年基金，保幼激素通過(guò)Tsf1調(diào)控果蠅鐵剝奪的機(jī)制研究, 2022.01- 2024.12，主持 <br>2.國(guó)家重點(diǎn)研發(fā)子課題，動(dòng)物源新食物資源中過(guò)敏原精準(zhǔn)化脫除技術(shù)研究，2023.12-2027.12，主持 <br>3.茶樹(shù)生物學(xué)與資源利用國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題：EGCG通過(guò)抑制鐵死亡改善帕金森病的機(jī)制研究, 2021.10-2023.09，主持 <br>4.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計(jì)劃B，JNK信號(hào)通路在鉛致腸道損傷中的作用機(jī)制研究，2022.04-2023.12，主持 <br>5.青年教師科研創(chuàng)新啟動(dòng)專(zhuān)項(xiàng)A項(xiàng)目，鉛暴露影響果蠅生長(zhǎng)發(fā)育的機(jī)制研究，2022.05-2024.05，主持 <br>6.青年教師科研創(chuàng)新啟動(dòng)專(zhuān)項(xiàng)B項(xiàng)目，果蠅保幼激素通過(guò)轉(zhuǎn)鐵蛋白Tsf1調(diào)控生殖的機(jī)制研究，2020.05-2022.04，主持
榮譽(yù)獎(jiǎng)項(xiàng)	<br>2022及2023年青年教師教學(xué)基本功比賽院級(jí)二等獎(jiǎng) <br>2024年青年教師教學(xué)基本功比賽院級(jí)一等獎(jiǎng) <br>2023年全國(guó)青年教師毒理學(xué)教學(xué)競(jìng)賽二等獎(jiǎng) <br>2024年指導(dǎo)本科生獲全國(guó)大學(xué)生生命科學(xué)競(jìng)賽國(guó)家級(jí)三等獎(jiǎng)、省級(jí)二等獎(jiǎng)

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