副教授

1、納米載藥
納米技術在藥物和功能性食品中的應用，主要是雙親分子自組裝納米體系，用于小分子活性因子的包封、輸運以及對生物大分子的結構調控及其遞送。
2、天然產(chǎn)物化學
天然活性成分的提取分離、結構改造及活性研究
3、藥物化學
阿爾茨海默病的早期診斷分子探針以及治療藥物的研究

1. 靶向淀粉樣蛋白的阿爾茨海默病分子探針研究，主持
2. 用于阿爾茨海默病診斷的磁共振顯像分子探針，主持
3. 葡萄糖基環(huán)保表面活性劑系列產(chǎn)品的研究開發(fā)，主持
4. 天然植物艾草活性成分提取分離工藝研究，主持
5. 抗真菌藥物艾氟康唑的合成工藝及工業(yè)化研究，主持
6. 化妝品中天然活性成分的研究及產(chǎn)業(yè)化，主持

代表性論文

1. Tiantian Xu, Jingwen Zhang, Risheng Jin, Rong Cheng, Xiaonan Wang, Chuanxun Yuan, Changsheng Gan*. Physicochemical properties, antioxidant activities and in vitro sustained release behavior of co-encapsulated liposomes as vehicle for vitamin E and β-carotene. Journal of the Science of Food and Agriculture, 2022, 102, 5759-5767

2. Changsheng Gan*, Rong Cheng, Kunliang Cai, Xiaonan Wang, Chenkun Xie, Tiantian Xu, Chuanxun Yuan, Interaction of calf thymus DNA and glucose-based gemini cationic surfactants with different spacer length: A spectroscopy and DLS study, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 267, 120606

3. Rong Cheng, Tiantian Xu, Chao Wang, Changsheng Gan*, The stabilization and antioxidant performances of coenzyme Q10-loaded niosomes coated by PEG and chitosan, Journal of Molecular Liquids, 2021, 325(1), 115194.

4. Kunliang Cai, Rong Cheng, Chao Wang, Yi Xia, Tiantian Xu, Changsheng Gan*, Interactions with ctDNA of novel sugar-based gemini cationic surfactants, International Journal of Biological Macromolecules, 2020, 156, 805-811.

5. Changsheng Gan*, Kunliang Cai, Xilin Qu, Hong Li, Lianggang Wei, Rong Cheng, Glucose-based novel gemini surfactants: Surface activities, aggregation properties and a preliminary study as nanocarrier for resveratrol, Journal of Molecular Liquids 2019, 283, 781-787.

6. Changsheng Gan*, Hong Li, Kunliang Cai. Novel Sugar-Based Gemini Surfactants and Their Surface Properties, Journal of Surfactants and Detergents, 2018, 21, 859-866.

7. Changsheng Gan*, Jingyi Hu, Dou-Dou Nan, Shanshan Wang, Hong Li. Synthesis and biological evaluation of curcumin analogs as β-amyloid imaging agents, Future Medicinal Chemistry, 2017, 9(14), 1587-1596.

8. Changsheng Gan*, Zhenzhen Zhao, Dou-Dou Nan, Binbin Yin, Jingyi Hu. Homoisoflavonoids as potential imaging agents for β-amyloid plaques in Alzheimer’s disease, European Journal of Medicinal Chemistry, 2014, 76, 125-131

9. Changsheng Gan*, Lin Zhou, Zhenzhen Zhao, Haoshu Wang. Benzothiazole Schiff-bases as potential imaging agentsfor β-amyloid plaques in Alzheimer’s disease, Medicinal Chemistry Research, 2013, 22(9), 4069-4074

10. Changsheng Gan*, Haoshu Wang, Zhenzhen Zhao, Binbin Yin. Sugar-Based Ester Quaternary Ammonium Compounds and Their Surfactant Properties, Journal of Surfactants and Detergents, 2014, 17, 465-470

11. Dou-Dou Nan, Chang-Sheng Gan, Chen-Wei Wang, Jin-Ping Qiao, Xin-Meng Wang, Jiang-Ning Zhou*. 6-Methoxy-indanone derivatives as potential probes for β-amyloid plaques in Alzheimer's disease. European Journal of Medicinal Chemistry 2016, 124, 117-128

專利
1.一種以茚酮和吩噻嗪為骨架結構的雜二聯(lián)體類化合物及用途，專利號：ZL 2011 1 0416785.7

2.一種呫噸酮類衍生物及其用途，專利號：ZL 2011 1 0434209.5

3.一種苯并噻唑類衍生物及其用途，專利號：ZL 2011 1 0434465.4

4.一種葡萄糖酯基季銨鹽陽離子表面活性劑及其合成方法，專利號：ZL 2012 1 0261510.5

5.一種葡萄糖基雙子陽離子表面活性劑及其合成方法，專利號：ZL 201710010183.9

6.葡萄糖基雙子非離子表面活性劑及其合成方法，專利號：ZL 201710932528.6

7.一種葡萄糖基雙子非離子表面活性劑、兩性表面活性劑及其合成方法，專利號：ZL 201710936090.9

8.一種具有緩解疲勞功能的中藥組合物及其應用，申請?zhí)枺?01611004592.X

9.以哌啶酮為核心的具有雙查爾酮骨架結構的姜黃素類似物及其衍生物以及應用，專利號：ZL 201711021369.0

1.安徽省科學技術獎三等獎，2011年