副教授

利用生物信息學(xué)分析肥胖相關(guān)代謝疾病、惡性腫瘤等復(fù)雜疾病的致病機(jī)理。
（1）利用多組學(xué)以及單細(xì)胞測序技術(shù)剖析復(fù)雜疾病致病機(jī)理；
（2）食品來源天然小分子減肥、改善肥胖及代謝的機(jī)理研究；
（3）基于高光譜與近紅外光譜技術(shù)的農(nóng)產(chǎn)品及中藥材產(chǎn)地溯源與食品摻假鑒別研究。

1.國家自然科學(xué)青年基金：多組學(xué)數(shù)據(jù)整合分析探究肝細(xì)胞癌相關(guān)RNA編輯位點(diǎn)及其功能影響2019.01-2021.12，項(xiàng)目主持人。
2.安徽省自然科學(xué)基金：基于生物數(shù)據(jù)整合的肝細(xì)胞癌患者RNA編輯組合調(diào)控模式研究，2019.07-2021.06，項(xiàng)目主持人。
3. 2025 年度安徽省食藥用菌功能活性與資源利用聯(lián)合共建重點(diǎn)實(shí)驗(yàn)室開放課題：基于近紅外光譜技術(shù)建立茯苓的產(chǎn)品指紋圖譜和摻假鑒定體系，2025.12.31-2027.12.31，項(xiàng)目主持人。
4. 企業(yè)委托橫向課題，散射光信號處理模型開發(fā)，2025.9.1-2026.2.28，項(xiàng)目主持人。
5.合肥工業(yè)大學(xué)博士專項(xiàng)科研資助基金：肥胖小鼠升麻提取物的代謝組學(xué)分析，2018.05-2020.04，項(xiàng)目主持人。
6.合肥工業(yè)大學(xué)應(yīng)用培育計(jì)劃項(xiàng)目: 特色中餐料理包的研發(fā)，2019.07-2020.07，項(xiàng)目主持人。
7.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升B計(jì)劃：肥胖相關(guān)代謝疾病中關(guān)鍵RNA編輯位點(diǎn)識別及功能分析，2022.05-2023.12，項(xiàng)目主持人。

代表性論文
1) Chen Juan#, Zhang Cheng-hui# Tao Tao, Zhang Xian, Lin Yan, Wang Fang-bin, Liu Hui-fang*, Liu Jian*. A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma. Communications Biology, 2024 Jul 9;7(1):838.
2) Chen Juan#, Yuan Jing-Jing#, Huang Li-Na#, Shi Qiang-Qiang, Zhang Xian, Qiu Ming-Hua*, Liu Jian*. Linoleic acid metabolism is implicated in the anti-obesity effects of actein in C57BL/6 mice. Biochemical Pharmacology. 2025 Mar;233:116793.
3) Chen Juan, Liu Hui-fang, Qiao Li-bo, Wang Fang-bin, Wang Lu, Lin Yan, Liu Jian*. Global RNA editing identification and characterization during human pluripotent-to-cardiomyocyte differentiation, Molecular Therapy-Nucleic Acids, 2021, 26: 879-891.
4) Chen Juan, Wang Lu, Wang Fangbin, Liu Jian*, Bai Zhenyu*. Genomic identification of RNA editing through integrating omics datasets and the clinical relevance in hepatocellular carcinoma, Frontiers in Oncology, 2020, 10: 37.
5) Yuan Jingjing, Nian Yin, Wang Xin, Shi Qiangqiang, Shui Shanshan, Cai Hao, Lin Yan, Zhang Xian, Wang Fangbin, Chen Juan*, Qiu Minghua*, Liu Jian*. Actein ameliorates diet-induced obesity through the activation of AMPK-mediated white fat browning. Phytomedicine. 2024 Nov;134:156009.
6) Tao Tao#, Xu Yanting#, Zhang Cheng-Hui, Zhang Xian*, Chen Juan*, Liu Jian*. Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Mar;1870(2):159585.
7) Zhang Zhixin, Zhao Linlin, Wang Jiahui, Chen Hao, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian*, Zhang Xian*. Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jun;1870(5):159620.
8) Wang Xin, Cai Hao, Shui Shanshan, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian* . Chrysin stimulates subcutaneous fat thermogenesis in mice by regulating PDGFR alpha and microRNA expressions, Journal of Agricultural and Food Chemistry, 2021, 69(21): 5897-5906.
9) Zhou Zhou, Chen Juan*, Zhang Zhixin, Wang Fangbin, Wang Lu, Lin Yan, Zhang Xian, Liu Jian*. Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences, 2022 Jul 1;174:106188.