食品生物技術系

利用生物信息學分析肥胖相關代謝疾病、惡性腫瘤等復雜疾病的致病機理。
（1）利用多組學以及單細胞測序技術剖析復雜疾病致病機理；
（2）食品來源天然小分子減肥、改善肥胖及代謝的機理研究；
（3）基于高光譜與近紅外光譜技術的農產品及中藥材產地溯源與食品摻假鑒別研究。

1.國家自然科學青年基金：多組學數(shù)據(jù)整合分析探究肝細胞癌相關RNA編輯位點及其功能影響2019.01-2021.12，項目主持人。
2.安徽省自然科學基金：基于生物數(shù)據(jù)整合的肝細胞癌患者RNA編輯組合調控模式研究，2019.07-2021.06，項目主持人。
3. 2025 年度安徽省食藥用菌功能活性與資源利用聯(lián)合共建重點實驗室開放課題：基于近紅外光譜技術建立茯苓的產品指紋圖譜和摻假鑒定體系，2025.12.31-2027.12.31，項目主持人。
4. 企業(yè)委托橫向課題，散射光信號處理模型開發(fā)，2025.9.1-2026.2.28，項目主持人。
5.合肥工業(yè)大學博士專項科研資助基金：肥胖小鼠升麻提取物的代謝組學分析，2018.05-2020.04，項目主持人。
6.合肥工業(yè)大學應用培育計劃項目: 特色中餐料理包的研發(fā)，2019.07-2020.07，項目主持人。
7.合肥工業(yè)大學學術新人提升B計劃：肥胖相關代謝疾病中關鍵RNA編輯位點識別及功能分析，2022.05-2023.12，項目主持人。

代表性論文
1) Chen Juan#, Zhang Cheng-hui# Tao Tao, Zhang Xian, Lin Yan, Wang Fang-bin, Liu Hui-fang*, Liu Jian*. A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma. Communications Biology, 2024 Jul 9;7(1):838.
2) Chen Juan#, Yuan Jing-Jing#, Huang Li-Na#, Shi Qiang-Qiang, Zhang Xian, Qiu Ming-Hua*, Liu Jian*. Linoleic acid metabolism is implicated in the anti-obesity effects of actein in C57BL/6 mice. Biochemical Pharmacology. 2025 Mar;233:116793.
3) Chen Juan, Liu Hui-fang, Qiao Li-bo, Wang Fang-bin, Wang Lu, Lin Yan, Liu Jian*. Global RNA editing identification and characterization during human pluripotent-to-cardiomyocyte differentiation, Molecular Therapy-Nucleic Acids, 2021, 26: 879-891.
4) Chen Juan, Wang Lu, Wang Fangbin, Liu Jian*, Bai Zhenyu*. Genomic identification of RNA editing through integrating omics datasets and the clinical relevance in hepatocellular carcinoma, Frontiers in Oncology, 2020, 10: 37.
5) Yuan Jingjing, Nian Yin, Wang Xin, Shi Qiangqiang, Shui Shanshan, Cai Hao, Lin Yan, Zhang Xian, Wang Fangbin, Chen Juan*, Qiu Minghua*, Liu Jian*. Actein ameliorates diet-induced obesity through the activation of AMPK-mediated white fat browning. Phytomedicine. 2024 Nov;134:156009.
6) Tao Tao#, Xu Yanting#, Zhang Cheng-Hui, Zhang Xian*, Chen Juan*, Liu Jian*. Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Mar;1870(2):159585.
7) Zhang Zhixin, Zhao Linlin, Wang Jiahui, Chen Hao, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian*, Zhang Xian*. Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jun;1870(5):159620.
8) Wang Xin, Cai Hao, Shui Shanshan, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian* . Chrysin stimulates subcutaneous fat thermogenesis in mice by regulating PDGFR alpha and microRNA expressions, Journal of Agricultural and Food Chemistry, 2021, 69(21): 5897-5906.
9) Zhou Zhou, Chen Juan*, Zhang Zhixin, Wang Fangbin, Wang Lu, Lin Yan, Zhang Xian, Liu Jian*. Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences, 2022 Jul 1;174:106188.