国产麻豆精品久久一二三,四川W搡BBB搡WBBB搡,亚洲精品色情AAA片

- 姓名：張爽
- 職務(wù)：
- 職稱：副教授、碩導(dǎo)
- 所屬系：藥物科學(xué)與工程系
- 郵箱：zhangshuang@hfut.edu.cn
- 辦公地點：食品與生物工程學(xué)院507

個人簡介
研究領(lǐng)域
科研項目
學(xué)術(shù)成果
榮譽獎項

學(xué)習(xí)經(jīng)歷：

1、2011年9月-2015年6月，畢業(yè)院校：中國海洋大學(xué)海洋生命學(xué)院（生命基地班），學(xué)歷：大學(xué)本科

2、2015年9月-2020年6月，畢業(yè)院校：南開大學(xué)生生命科學(xué)學(xué)院，學(xué)歷：博士研究生

工作經(jīng)歷：

2020年12月-至今，合肥工業(yè)大學(xué)食品與生物工程學(xué)院，副教授、碩導(dǎo)

研究方向：代謝疾病（肝臟疾病、心血管疾病）的藥理學(xué)和分子機理研究。
招生方向：歡迎對基礎(chǔ)醫(yī)學(xué)和代謝疾病、藥理學(xué)和分子靶點研究方向感興趣的生物學(xué)、生物技術(shù)、藥學(xué)、生物信息學(xué)、食品科學(xué)等相關(guān)專業(yè)的同學(xué)報考碩士研究生，一起發(fā)現(xiàn)疾病領(lǐng)域的未知。

1.國家自然科學(xué)基金青年項目，在研，主持。
2.安徽省自然科學(xué)基金青年項目，在研，主持。
3.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計劃A項目，結(jié)題，主持。
4.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計劃B項目，在研，主持。
5.企業(yè)合作委托項目，編號W2022JSFW0781，在研，主持。
6.企業(yè)合作委托項目，編號W2022JSFW0883，在研，主持。
7.產(chǎn)學(xué)研合作項目，編號W2023JSFW0071，在研，主持。
8.產(chǎn)學(xué)研合作項目，編號W2023JSFW0567，在研，主持。
9.復(fù)方中藥創(chuàng)新數(shù)智研發(fā)，編號W2024JSFW0169，在研，主持。

代表性論文：
1.Shuang Zhang, Fangling Guo, Miao Yu, Xiaoxiao Yang, Zhi Yao, Qi Li, Zhuo Wei, Ke Feng, Peng Zeng, Dan Zhao, Xiaoju Li, Yan Zhu, Qing Robert Miao, Yasuko Iwakiri, Yuanli Chen*, Jihong Han*, Yajun Duan*. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495.
2.Jiaqi Li#, Shuang Zhang#, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan. Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring. EMBO Rep. 2024.
3.Shuang Zhang#, Miao Yu#, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han*, Yajun Duan*. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060.
4.Miao Yu#, Shuang Zhang#, Fangling Guo, Xiaoxiao Yang, Qi Li, Zhuo Wei, Jihong Han*, Yajun Duan*, Yuanli Chen*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429.
5.Zequn Yin#, Xuerui Wang#, Shihong Zheng, Peichang Cao, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Jihong Han, Yajun Duan, Xiaoxiao Yang*, Shuang Zhang*. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455.
6.Xuerui Wang#, Zequn Yin#, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao,Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang*, Xiaoxiao Yang*. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964.
7.Xuerui Wang, Zequn Yin, Xianshe Meng, Daigang Yang, Huawen Meng, Chenzhong Liao, Lingling Wei, Yuanli Chen, Xiaoxiao Yang, Jihong Han, Yajun Duan*, Shuang Zhang*. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. J Funct Foods. 92 (2022) 105060.
8.Huaxin Li#, Mengxue Zhang#, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan*, Shuang Zhang*. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food Funct. 2022 Sep 22;13(18):9576-9588.
9.Feng Zhang#, Mengyao Wang#, Yang Zha, Jie Zhou, Jihong Han*, Shuang Zhang*. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023 Jan 1;15(1):223.
10.Yuanli Chen, Shu Yang, Lipei Liu, Xiaoxiao Yang, Yajun Duan, Shuang Zhang*, Jihong Han*. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. Eur J Pharmacol. 2023 Jan 5:938:175428.
11.Miao Yu, Meixiu Jiang, Yuanli Chen, Shuang Zhang, Wenwen Zhang, Xiaoxiao Yang, Xiaoju Li, Yan Li, Shengzhong Duan, Jihong Han, Yajun Duan. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89.
12.Qi Li, Yi Chen, Dan Zhao, Zhuo Wei, Shuang Zhang, Yuanli Chen, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Xiumei Gao, Pengzhi Dong, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59.
13.Qi Li, Yi Chen, Dan Zhao, Shu Yang, Shuang Zhang, Zhuo Wei, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180.
14.Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117.
15.Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860.
16.Dan Zhao, Chao Xue, Jiaqi Li, Ke Feng, Peng Zeng, Yuanli Chen, Yajun Duan, Shuang Zhang, Xiaoju Li, Jihong Han, Xiaoxiao Yang. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312.
17.Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654.
18.Yingquan Liang, Guilan Chen, Feng Zhang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan, Maoyun Yu, Shuang Zhang, Jihong Han. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916.
19.Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334.
20.Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624.
21.Buchun Zhang, Rong Huang, Daigang Yang, Guilan Chen, Yuanli Chen, Jihong Han, Shuang Zhang, LiKun Ma, XiaoXiao Yang. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198.
22.Xiaolin Wang, Yanfang Yang, Dan Zhao, Shuang Zhang, Yi Chen, Yuanli Chen, Ke Feng, Xiaoju Li, Jihong Han, Yasuko Iwakiri, Yajun Duan, Xiaoxiao Yang. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561.
23.Yali Yan, Mengmeng Zhu, Jialing Ma, Xiaoyu He, Xiaoxiao Yang, Hongmei Xu, Meixiu Jiang, Shuang Zhang, Yajun Duan, Jihong Han, Yuanli Chen. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227.
24.Dan Zhao, Chao Xue, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen, Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Jihong Han. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomed Pharmacother. 2022 Sep:153:113444.
25.Xiaoyu He, Mengmeng Zh, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Baotong Zhang, Dachen Zhou, Shuang Zhang, Xiaoxiao Yang, Yajun Duan, Jihong Han, Yuanli Chen. Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. Acta Pharmacol Sin. 2023 Mar;44(3):635-646.
26.Juan Zheng, Shengnan Wang, Tingting Zhang, Huaxin Li, Mengmeng Zhu, Xiaoning Wei, Yu Ge, Xiaoxiao Yang, Shuang Zhang, Hongmei Xu, Yajun Duan, Lipei Liu, Yuanli Chen. Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway. Int Immunopharmacol. 2023 Jul:120:110378.
27.Huawen Meng, Zhenbao Shen, Xianshe Meng, Leng Wei, Zequn Yin, Xuerui Wang, Ting-Feng Zou, Zhigang Liu, Tianxiang Wang, Shuang Zhang, Yuanli Chen, Xiaoxiao Yang, Qingshan Li, Yajun Duan. Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway. Bioorg Chem. 2023 Sep:138:106654.
專利：
1.治療葡萄糖和或脂質(zhì)代謝紊亂的藥物和治療葡萄糖和或脂質(zhì)代謝紊亂的方法（美國專利），專利授權(quán)號：132257-00102.
2.Nogo-B抑制劑在制備治療糖脂代謝紊亂藥物中的應(yīng)用和治療糖脂代謝紊亂的藥物，公開。

1.2018年中華醫(yī)學(xué)科學(xué)技術(shù)獎三等獎“動脈粥樣硬化干預(yù)靶點與機制研究”。
2.2018年第十四屆全國脂質(zhì)與脂蛋白學(xué)術(shù)會議青年優(yōu)秀論文大賽獎。
3.2018年美國Experimental Biology 2018學(xué)術(shù)會議 ASBMB Travel Award。
4.2019年動脈粥樣硬化干預(yù)靶點與機制研究中華醫(yī)學(xué)會科技獎三等獎。
5.2019年南開大學(xué)博士研究生國家獎學(xué)金、博士研究生一等獎學(xué)金。
6.2020年安徽省細胞生物學(xué)會口頭報告一等獎。
7.2022年安徽省病理生理學(xué)心血管疾病專業(yè)委員會優(yōu)秀墻報特等獎。

職務(wù)：		職稱：	副教授、碩導(dǎo)
所屬系：	藥物科學(xué)與工程系	郵箱：	zhangshuang@hfut.edu.cn
辦公地點：	食品與生物工程學(xué)院507	學(xué)術(shù)成果	<br>代表性論文： <br>1.Shuang Zhang, Fangling Guo, Miao Yu, Xiaoxiao Yang, Zhi Yao, Qi Li, Zhuo Wei, Ke Feng, Peng Zeng, Dan Zhao, Xiaoju Li, Yan Zhu, Qing Robert Miao, Yasuko Iwakiri, Yuanli Chen, Jihong Han, Yajun Duan. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495. <br>2.Jiaqi Li#, Shuang Zhang#, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan. Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring. EMBO Rep. 2024. <br>3.Shuang Zhang#, Miao Yu#, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han, Yajun Duan. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060. <br>4.Miao Yu#, Shuang Zhang#, Fangling Guo, Xiaoxiao Yang, Qi Li, Zhuo Wei, Jihong Han, Yajun Duan, Yuanli Chen. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429. <br>5.Zequn Yin#, Xuerui Wang#, Shihong Zheng, Peichang Cao, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Jihong Han, Yajun Duan, Xiaoxiao Yang, Shuang Zhang. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455. <br>6.Xuerui Wang#, Zequn Yin#, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao,Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang, Xiaoxiao Yang. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964. <br>7.Xuerui Wang, Zequn Yin, Xianshe Meng, Daigang Yang, Huawen Meng, Chenzhong Liao, Lingling Wei, Yuanli Chen, Xiaoxiao Yang, Jihong Han, Yajun Duan, Shuang Zhang. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. J Funct Foods. 92 (2022) 105060. <br>8.Huaxin Li#, Mengxue Zhang#, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food Funct. 2022 Sep 22;13(18):9576-9588. <br>9.Feng Zhang#, Mengyao Wang#, Yang Zha, Jie Zhou, Jihong Han, Shuang Zhang. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023 Jan 1;15(1):223. <br>10.Yuanli Chen, Shu Yang, Lipei Liu, Xiaoxiao Yang, Yajun Duan, Shuang Zhang, Jihong Han. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. Eur J Pharmacol. 2023 Jan 5:938:175428. <br>11.Miao Yu, Meixiu Jiang, Yuanli Chen, Shuang Zhang, Wenwen Zhang, Xiaoxiao Yang, Xiaoju Li, Yan Li, Shengzhong Duan, Jihong Han, Yajun Duan. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89. <br>12.Qi Li, Yi Chen, Dan Zhao, Zhuo Wei, Shuang Zhang, Yuanli Chen, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Xiumei Gao, Pengzhi Dong, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59. <br>13.Qi Li, Yi Chen, Dan Zhao, Shu Yang, Shuang Zhang, Zhuo Wei, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180. <br>14.Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117. <br>15.Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860. <br>16.Dan Zhao, Chao Xue, Jiaqi Li, Ke Feng, Peng Zeng, Yuanli Chen, Yajun Duan, Shuang Zhang, Xiaoju Li, Jihong Han, Xiaoxiao Yang. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312. <br>17.Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654. <br>18.Yingquan Liang, Guilan Chen, Feng Zhang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan, Maoyun Yu, Shuang Zhang, Jihong Han. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916. <br>19.Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334. <br>20.Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. <br>21.Buchun Zhang, Rong Huang, Daigang Yang, Guilan Chen, Yuanli Chen, Jihong Han, Shuang Zhang, LiKun Ma, XiaoXiao Yang. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198. <br>22.Xiaolin Wang, Yanfang Yang, Dan Zhao, Shuang Zhang, Yi Chen, Yuanli Chen, Ke Feng, Xiaoju Li, Jihong Han, Yasuko Iwakiri, Yajun Duan, Xiaoxiao Yang. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561. <br>23.Yali Yan, Mengmeng Zhu, Jialing Ma, Xiaoyu He, Xiaoxiao Yang, Hongmei Xu, Meixiu Jiang, Shuang Zhang, Yajun Duan, Jihong Han, Yuanli Chen. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227. <br>24.Dan Zhao, Chao Xue, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen, Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Jihong Han. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomed Pharmacother. 2022 Sep:153:113444. <br>25.Xiaoyu He, Mengmeng Zh, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Baotong Zhang, Dachen Zhou, Shuang Zhang, Xiaoxiao Yang, Yajun Duan, Jihong Han, Yuanli Chen. Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. Acta Pharmacol Sin. 2023 Mar;44(3):635-646. <br>26.Juan Zheng, Shengnan Wang, Tingting Zhang, Huaxin Li, Mengmeng Zhu, Xiaoning Wei, Yu Ge, Xiaoxiao Yang, Shuang Zhang, Hongmei Xu, Yajun Duan, Lipei Liu, Yuanli Chen. Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway. Int Immunopharmacol. 2023 Jul:120:110378. <br>27.Huawen Meng, Zhenbao Shen, Xianshe Meng, Leng Wei, Zequn Yin, Xuerui Wang, Ting-Feng Zou, Zhigang Liu, Tianxiang Wang, Shuang Zhang, Yuanli Chen, Xiaoxiao Yang, Qingshan Li, Yajun Duan. Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway. Bioorg Chem. 2023 Sep:138:106654. <br>專利： <br>1.治療葡萄糖和或脂質(zhì)代謝紊亂的藥物和治療葡萄糖和或脂質(zhì)代謝紊亂的方法（美國專利），專利授權(quán)號：132257-00102. <br>2.Nogo-B抑制劑在制備治療糖脂代謝紊亂藥物中的應(yīng)用和治療糖脂代謝紊亂的藥物，公開。
研究領(lǐng)域	<br>研究方向：代謝疾病（肝臟疾病、心血管疾病）的藥理學(xué)和分子機理研究。 <br>招生方向：歡迎對基礎(chǔ)醫(yī)學(xué)和代謝疾病、藥理學(xué)和分子靶點研究方向感興趣的生物學(xué)、生物技術(shù)、藥學(xué)、生物信息學(xué)、食品科學(xué)等相關(guān)專業(yè)的同學(xué)報考碩士研究生，一起發(fā)現(xiàn)疾病領(lǐng)域的未知。	科研項目	<br>1.國家自然科學(xué)基金青年項目，在研，主持。 <br>2.安徽省自然科學(xué)基金青年項目，在研，主持。 <br>3.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計劃A項目，結(jié)題，主持。 <br>4.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計劃B項目，在研，主持。 <br>5.企業(yè)合作委托項目，編號W2022JSFW0781，在研，主持。 <br>6.企業(yè)合作委托項目，編號W2022JSFW0883，在研，主持。 <br>7.產(chǎn)學(xué)研合作項目，編號W2023JSFW0071，在研，主持。 <br>8.產(chǎn)學(xué)研合作項目，編號W2023JSFW0567，在研，主持。 <br>9.復(fù)方中藥創(chuàng)新數(shù)智研發(fā)，編號W2024JSFW0169，在研，主持。
榮譽獎項	<br>1.2018年中華醫(yī)學(xué)科學(xué)技術(shù)獎三等獎“動脈粥樣硬化干預(yù)靶點與機制研究”。 <br>2.2018年第十四屆全國脂質(zhì)與脂蛋白學(xué)術(shù)會議青年優(yōu)秀論文大賽獎。 <br>3.2018年美國Experimental Biology 2018學(xué)術(shù)會議 ASBMB Travel Award。 <br>4.2019年動脈粥樣硬化干預(yù)靶點與機制研究中華醫(yī)學(xué)會科技獎三等獎。 <br>5.2019年南開大學(xué)博士研究生國家獎學(xué)金、博士研究生一等獎學(xué)金。 <br>6.2020年安徽省細胞生物學(xué)會口頭報告一等獎。 <br>7.2022年安徽省病理生理學(xué)心血管疾病專業(yè)委員會優(yōu)秀墻報特等獎。

藥物科學(xué)與工程系