藥物科學(xué)與工程系

    • 姓名:王玉
    • 職務(wù):
    • 職稱:講師、碩導(dǎo)
    • 所屬系:藥物科學(xué)與工程系
    • 郵箱:yuwang@hfut.edu.cn
    • 辦公地點(diǎn):食生樓1111室
  • 個(gè)人簡介
  • 研究領(lǐng)域
  • 科研項(xiàng)目
  • 學(xué)術(shù)成果
  • 榮譽(yù)獎項(xiàng)

學(xué)習(xí)經(jīng)歷:

20139-20176月            合肥工業(yè)大學(xué)                   學(xué)士

20179-20236月            中國科學(xué)技術(shù)大學(xué)               博士

工作經(jīng)歷:

202311-至今             合肥工業(yè)大學(xué)                  講師


職務(wù): 職稱: 講師、碩導(dǎo)
所屬系: 藥物科學(xué)與工程系 郵箱: yuwang@hfut.edu.cn
辦公地點(diǎn): 食生樓1111室 學(xué)術(shù)成果 <br>以第一/通訊作者(共同)在Nature Commun.、 J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、CCS Chem.、Chem. Comm. 等期刊發(fā)表研究論文10余篇。
<br>1.Y. Wang, J. Fan, X. Meng, Q. Shu, Y. Wu, G. C. Chu*, R. Ji, Y. Ye, X. Wu, J. Shi, H. Deng, L. Liu*, Y.-M. Li*. Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells. Nat Commun. 2025, 16, 415.
<br>2.Y. Wang, L. Liu, Q. Zheng, Y. Wu, Z. Su, R. Yuan, Q. Xia, B, Wang, Y. Yu*, Y.-M. Li*. Synergizing Structure-Guided Photocaged Linear Diubiquitin-Dha with Biotinylated Linear-Fab for Time-Resolved Profiling of Interactors in Living Cells. J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c15159.
<br>3.Y. Wang, J. Chen, X. Hua, X. Meng, H. Cai, R. Wang, J. Shi, H. Deng, L. Liu, Y.-M. Li*. Photocaging of Activity-Based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy. Angew. Chem. Int. Ed. 2022, 61, e202203792.
<br>4.L. Liu, P. Li, S. Yang, D. Yan, B. Wang, Y.-M. Li*, Y. Wang*. Acetylacetone-Modified Ubiquitin C-Terminus Enables Specific Capture of Sulfenylated Deubiquitinases. Chem Commun. 2026, DOI: 10.1039/D5CC05543A.
<br>5.Q. Xia, X. Meng, Y. Wang*, R. Yuan, P. Li, L. Liu, Y.-M. Li*. A cell-permeable Ub-Dha probe for profiling E1-E2-E3 enzymes in live cells. Chem Commun. 2024, 60, 4342-4345.
<br>6.P. Li, X. Han, B. Wang, Y. Guo, Y. Wang*, Y.-M. Li*. Efficient Synthesis of Cleavable CPP-cargo Conjugate via Low-equivalent of CPP Activated by 2,2’-dithiodipyridine. ChemBioChem. 2025, 26, e202500032.
<br>7.L. Liu, B. Wang, S. Yang, W. Wang, Y. Wang*, Y.-M. Li*. Semi-synthesis of functionalized cell-permeable ubiquitin probes via SrtA-mediated ligation. Org. Biomol. Chem. 2025, 23, 3459.
<br>8.D. Yang, B. Wang, Z. Song, J. Tang, N. Wang, J. Wang*, Y. Wang*, Y.-M. Li. One-step solid-phase synthesis of activated cell-penetrating peptides for cytosolic delivery of protein. Tetrahedron Lett. 2024, 153, 155385.
<br>9.J. Chen, Y. Wang*, R. Wang, R. Yuan, G-C. Chu *, Y.-M. Li*. Chemical synthesis of on demand-activated SUMO-based probe by a photocaged glycine-assisted strategy. Bioorg. Med. Chem. Lett. 2023, 94, 129460.
<br>10.Y. Wang, C. Chen, X. Meng, J. Fan, M. Pan, J. Chen, H. Deng, J. Shi*, L. Liu, Y.-M. Li*. Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO Chain-Specific Interacting Proteins. CCS. Chem. 2020, 2, 1157-1168.
<br>11.Y. Wang, Q. Xia, X. Hua, Y. Guo, J. Shi*, Y.-M. Li*. Semi-synthesis of biotin-bearing activity-based ubiquitin probes through sequential enzymatic ligation, N-S acyl transfer and aminolysis reaction. Chin. Chem. Lett. 2023, 34, 108010.
<br>12.L. J. Liang#, Y. Wang#, X. Hua#, R. Yuan, Q. Xia, R. Wang, C. Li, G. Chu, L. Liu*, Y.-M. Li*. A cell-permeable stimuli-responsive ubiquitin probe for time-resolved monitoring of substrate ubiquitination in live cells. JACS Au 2023, 3, 2873-2882. (#: equal contribution)
研究領(lǐng)域 <br>研究方向聚焦翻譯后修飾光激活蛋白工具的化學(xué)構(gòu)建與在體應(yīng)用,形成 “探針設(shè)計(jì) - 高效遞送 - 功能篩查” 的完整體系:
<br>1)“光籠”蛋白探針設(shè)計(jì)與合成;
<br>2)合成蛋白工具的活細(xì)胞遞送;
<br>3)翻譯后修飾蛋白互作組的在體篩查。
科研項(xiàng)目 <br>1.國家自然科學(xué)基金青年項(xiàng)目,2025-2027,主持
<br>2.合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計(jì)劃A項(xiàng)目,2024-2025,主持
<br>3.合肥工業(yè)大學(xué)青年教師科研創(chuàng)新啟動專項(xiàng)A項(xiàng)目,2024-2026,主持
榮譽(yù)獎項(xiàng) <br>第一屆化學(xué)生物學(xué)研究生前言論壇優(yōu)秀墻報(bào)獎
<br>第二十屆化學(xué)與材料科學(xué)研究生中文學(xué)術(shù)年會三等獎

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