副教授

    • 姓名:張弦
    • 職務(wù):
    • 職稱:副教授、碩導(dǎo)
    • 所屬系:食品科學與工程系
    • 郵箱:zhangxian@hfut.edu.cn; zhangxian0426@hotmail.com
    • 辦公地點:食生樓505
  • 個人簡介
  • 研究領(lǐng)域
  • 科研項目
  • 學術(shù)成果
  • 榮譽獎項

學習經(jīng)歷:

2013.09-2016.06合肥工業(yè)大學食品與生物工程學院,食品科學與工程,博士

2010.09-2013.06合肥工業(yè)大學食品與生物工程學院,生物學,碩士

2006.09-2010.06安徽師范大學生命科學學院,生物科學,學士

工作經(jīng)歷:

2021.12-至今 合肥工業(yè)大學食品與生物工程學院,副教授

2016.10-2021.10美國哈佛大學醫(yī)學院,博士后

職務(wù): 職稱: 副教授、碩導(dǎo)
所屬系: 食品科學與工程系 郵箱: zhangxian@hfut.edu.cn; zhangxian0426@hotmail.com
辦公地點: 食生樓505 學術(shù)成果 <br>代表性論文:<br>
<br>1.Zhang X#(第一作者), Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J*, Liu Z* and Shi GP*. IL18 signaling causes islet beta cell development and insulin secretion via different receptors on acinar and beta cells. Developmental Cell. 2022;57(12):1496-511 e6. 2<br>
<br>2.Zhang X#(第一作者), Luo S#, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL, Meppen M, Vromman A, Flavell RA, Hotamisligil GS, Liu J, Libby P, Liu Z* and Shi GP*. Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation. Nature Communications. 2022;13(1):7582.<br>
<br>3.Wang J#, Zhang Z, Lin Y, Chen J, Wang F, Wang L, Liu J*, Zhang X*(通訊作者). Diet Supplementation of Luteolin before Fatty Liver Formation Improves Hepatic Steatosis in Obese Mice by Inhibiting Visceral Adipose Tissue Lipolysis. Molecular Nutrition & Food Research. 2023, e2200478.<br>
<br>4.Zhang Z#, Wang J, Lin Y, Chen J, Liu J*, and Zhang X*(通訊作者). Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues. Critical Reviews in Food Science and Nutrition. 2022:1-15.<br>
<br>5.Zhang Y#, Liu T#, Deng Z#, Fang W#, Zhang X#(第一作者), Zhang S, Wang M, Luo S, Meng Z, Liu J, Sukhova GK, Li D, McKenzie ANJ, Libby P, Shi GP*, Guo J*. Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. Advanced Science, 2023, 10(7): e220695.(中科院1區(qū)Top,影響因子17.521)<br>
<br>6.Zhang X#(第一作者), Li J, Luo SY, Wang MJ, Huang Q, Deng ZY, Febbo C, Daoui A, Liew PX, Sukhova GK, Metso J, Jauhiainen M, Shi GP*, Guo JL*. IgE contributes to atherosclerosis and obesity by affecting macrophage polarization, macrophage protein network, and foam cell formation. Arteriosclerosis Thrombosis and Vascular Biology. 2020;40: 597-610. 23<br>
<br>7.Zhang X#(第一作者), Wang X#, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP*, Liu J*. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Reports. 2019;28(3): 792-803. 40<br>
<br>8.Zhang X#(第一作者), Zhou Y#, Yu X, Huang Q, Fang WQ, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP*. Differential roles of cysteinyl cathepsins in TGF-β signaling and tissue fibrosis. iScience. 2019;19: 607-622. 18<br>
<br>9.Zhang X#(第一作者), Huang Q#, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J*, Shi GP*. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019;1865(6):1690-1700. 14<br>
<br>10.Zhang X#(第一作者), Luo SY, Wang MJ, Shi GP*. Cysteinyl cathepsins in cardiovascular diseases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2020;1868(4):140360. 10<br>
<br>11.Zhang X#(第一作者), Zhang QX, Wang X, Zhang L, Qu W, Bao B, Liu CA, and Liu J*. Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1alpha pathway-mediated mechanism. International Journal of Obesity. 2016;40(12): 1841-1849. 86<br>
<br>12.Dong J#, Zhang X#(第一作者), Zhang L, Bian HX, Xu N, Bao B, and Liu J. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1. Journal of Lipid Research. 2014;55(3):363-374.<br>
<br>13.Zhao L#, Zheng M, Cai H, Chen J, Lin Y, Wang F, Wang L, Zhang X, and Liu J*. The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation. The Journal of Nutritional Biochemistry. 2022;112:109208.<br>
<br>14.Zhou Z#, Chen J*, Zhang ZX, Wang FB, Wang L, Lin Y, Zhang X, and Liu J*. Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences. 2022;174:106188.<br>
<br>15.Li J#, Chen J, Wang L, Lin Y, Zhang X, Liu J*, and Wang F*. Characterization of the response of Escherichia coli to l-fucose in bacterial swimming motility. Journal of Basic Microbiology. 2022;62(5):584-92.<br>
<br>16.Liu CL#, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang J*, and Shi GP*. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nature Communications. 2019;10(1):3978.<br>
<br>17.Liu CL#, Ren JY, Wang YZ, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J*, and Shi GP*. Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. European Heart Journal. 2019;ehz856.<br>
<br>18.Li J#, Deng Z#, Zhang X, Liu F, Yang C, and Shi GP*. Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms. The FASEB Journal. 2020;34:3091-3104.<br>
<br>19.Wang Y#, Liu CL, Fang W, Zhang X, Yang C, Li J, Liu J, Sukhova GK, Gurish MF, Libby P, Shi GP*, and Zhang J*. Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of <br><br>20.Fang W#, He A#, Xiang MX, Lin Y, Wang Y, Li J, Yang C, Zhang X, Liu CL, Sukhova GK, Barascuk N, Larsen L, Karsdal M, Libby P, and Shi GP*. Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2019;127:44-56.<br>
<br>21.Liu CL#, Guo J#, Zhang X, Sukhova GK, Libby P, and Shi GP*. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nature Reviews Cardiology. 2018;15(6):351-370.<br>
<br>22.Zhang L#, Han YJ, Zhang X, Wang X, Bao B, Qu W, and Liu J*. Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKalpha1 signaling in adipose tissue macrophages. Diabetologia. 2016;59(10):2219-2228.<br>
<br>23.Xu N#, Zhang L#, Dong J, Zhang X, Chen YG, Bao B, and Liu J*. Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Molecular Nutrition & Food Research. 2014;58(6):1258-1268.<br>
研究領(lǐng)域 <br>1.糖脂代謝的免疫調(diào)控機制
以IL18信號通路和肥大細胞為對象,研究脂肪組織、胰腺等糖脂代謝穩(wěn)態(tài)調(diào)控組織中細胞間的互作模式和信息交流機制。
<br>2.肥胖和相關(guān)代謝疾病(糖尿病、心血管疾病等)的免疫-代謝調(diào)控
基于糖脂代謝的免疫調(diào)控機制,探究該機制在肥胖和相關(guān)代謝疾病中發(fā)揮的作用。
<br>3.細胞代謝穩(wěn)態(tài)的營養(yǎng)調(diào)控
基于IL18信號通路和肥大細胞的活性,研究黃酮類等生物活性物質(zhì)對細胞代謝穩(wěn)態(tài)的調(diào)控、對肥胖和相關(guān)代謝疾病的干預(yù)作用。
<br>歡迎生物學、生物工程、食品科學與工程、食品工程等專業(yè)學生報考。
科研項目 <br>1.國家自然科學基金青年項目:IL18作為棕色脂肪因子通過NCC調(diào)控機體能量代謝的機制研究(項目號32200630),2023.01-2025.12,主持人。
<br>2.合肥工業(yè)大學人才引進項目:IL18和MC調(diào)控肥胖及相關(guān)代謝疾病的機制研究(項目號13020-03712022006),2022.3-2025.3,主持人。
<br>3.海南醫(yī)學院急救與創(chuàng)傷研究教育部重點實驗室開放基金:半胱氨酸組織蛋白酶調(diào)節(jié)急性腎損傷的機制研究(項目號KLET-202119),2022.01 -2023.12,主持人。
<br>4.美國心臟協(xié)會American Heart Association (AHA) post-doctoral fellowship:Role of subcutaneous fat mast cells in adipose tissue thermogenesis and systemic energy expenditure (項目號18POST34050043),2018.07-2020.06,主持人。
榮譽獎項 <br>1.榮譽、獎勵
<br>1)2023年安徽省青年“百人計劃”
<br>2)2022年安徽省高層次創(chuàng)新創(chuàng)業(yè)人才
<br>3)合肥工業(yè)大學“黃山學者”學術(shù)骨干
<br>4)2015年博士研究生國家獎學金

<br>2.社會兼職
<br>1)《Frontiers in Immunology》客座編輯
<br>2)《Cell Reports》審稿人

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