食品科學(xué)與工程系

食品營(yíng)養(yǎng)與安全
（1）有毒重金屬對(duì)神經(jīng)系統(tǒng)的損傷作用及其機(jī)理研究
（2）食品營(yíng)養(yǎng)成分的神經(jīng)保護(hù)作用及機(jī)理研究

（1）國(guó)家自然科學(xué)基金青年基金項(xiàng)目，2023.01-2025.12，主持。
（2）合肥工業(yè)大學(xué)學(xué)術(shù)新人提升計(jì)劃B項(xiàng)目，2024.04-2026.04，主持。
（3）橫向項(xiàng)目“牡丹功能性食品系列產(chǎn)品研發(fā)”，2023.05-2026.05，主持。
（4）合肥工業(yè)大學(xué)青年教師科研創(chuàng)新啟動(dòng)專(zhuān)項(xiàng)，2022.02-2024.02，主持。

論文：
1: Gu X, Shen N, Huang C, Wang HL* Pb inhibited C2C12 myoblast differentiation by regulating HDAC2. Toxicology. 2023 Oct 4;499:153639.
2: Gu X, Bi N, Wang T, Huang C, Wang R, Xu Y, Wang HL*. Probiotic Lactobacillus rhamnosusGR-1 supplementation attenuates Pb-induced learning and memory deficits by reshaping the gut microbiota. Front Nutr. 2022 Jul 19;9:934118.
3: Gu X, Huang X, Li D, Bi N, Yu X, Wang HL*. Nuclear accumulation of histone deacetylase 4 (HDAC4) by PP1-mediated dephosphorylation exerts neurotoxicity in Pb-exposed neural cells. Neurotoxicology. 2020 Dec;81:395-405.
4: Gu X, Han M, Du Y, Wu Y, Xu Y, Zhou X, Ye D, Wang HL*. Pb disrupts autophagic flux through inhibiting the formation and activity of lysosomes in neural cells. Toxicol In Vitro. 2019 Mar;55:43-50.
5: Gu X, Xu Y, Xue WZ, Wu Y, Ye Z, Xiao G, Wang HL*. Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment. Cell Death Dis. 2019 Sep 11;10(9):671.
6: Huang C, Wang R, Wang Y, Liu H, Chen XT, Gu X*, Wang HL*. Sialic Acid Enhanced the Antistress Capability under Challenging Situations by Increasing Synaptic Transmission. J Nutr. 2023 Sep;153(9):2561-2570.
7. Wang M, Xia Y, Ai S, Gu X*, Wang HL*. Kaempferol improves Pb-induced cognitive impairments via inhibiting autophagy. J Nutr Biochem. 2024;125:109556.