瞿昊博士以構(gòu)建食品生物傳感的分子識別材料體系為核心內(nèi)容,圍繞如何發(fā)掘、優(yōu)化與利用識別材料的基礎“方法學”問題進行了系統(tǒng)研究。截止目前已在國際著名期刊如J. Am. Chem. Soc., ACS Nano, Phys. Rev. X, J. Agric. Food Chem., ACS Sens., Biosens. Bioelectron., Food Chem.等上發(fā)表第一作者或通訊作者高質(zhì)量論文20余篇。研究成果入選J. Am. Chem. Soc., J. Agric. Food Chem., Talanta等封面,并受到科技日報頭版、中國科學報、安徽日報、中新網(wǎng)、新華網(wǎng)、人民網(wǎng)、Science Trends等重要媒體報道。先后承擔國家自然科學基金面上和青年項目、科技部重點研發(fā)計劃子課題、安徽省科技重大專項、安徽省自然科學基金、中央高校基本業(yè)務費校級專項等項目。于第三屆、第四屆中國核酸適配體學術研討會做大會報告,并任第四屆會議學術委員會成員。授權(quán)發(fā)明專利6件,參編國家標準2項。現(xiàn)任安徽省檢驗檢測學會理事、Research期刊青年編委等。
代表性論文
第一作者論文:
1.Hao Qu, Manyi Zheng, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng*, Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling, Angewandte Chemie International Edition, 2023, 62: e202214045.
2.Hao Qu*, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng, Measuring Aptamer Folding Energy Using a Molecular Clamp, Journal of the American Chemical Society, 2020, 142(27): 11743-11749.(封面論文)
3.Hao Qu, Andrew T. Csordas, Jinpeng Wang, Seung Soo Oh, Michael S. Eisenstein, Hyongsok Tom Soh*, Rapid and Label-Free Strategy to Isolate Aptamers for Metal Ions, ACS Nano, 2016, 10(8): 7558-7565.
4.Hao Qu, Giovanni Zocchi*, How Enzymes Work: A Look through the Perspective of Molecular Viscoelastic Properties, Physical Review X, 2013, 3: 011009.
5.Hao Qu, Yong Wang, Chiao-Yu Tseng, Giovanni Zocchi*, Critical torque for kink formation in double stranded DNA, Physical Review X, 2011, 1: 021008.
6.Hao Qu, Lu Wang*, Jian Liu*, Lei Zheng*, Direct Screening for Cytometric Bead Assays for Adenosine Triphosphate, ACS Sensors, 2018, 3(10): 2071–2078.
通訊作者論文:
1.Songjia Luo#, Rongrong Wang#, Lu Wang#, Hao Qu*, Lei Zheng*, Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor, Biosensors & Bioelectronics, 2022, 210: 114319.
2.Yuhong Wang, Hao Qu*, Rongrong Wang, Baolei Dong, Lei Zheng*, Label-Free Biosensing of Mercury(II) in Milk Using an Aptamer-Gated Graphene Field-Effect Transistor, Journal of Electroanalytical Chemistry, 2022, 904: 115931.
3.Rongrong Wang, Yong Cao, Hao Qu*, Yanbo Wang, Lei Zheng*, Label-free detection of Cu(II) in fish using a graphene field-effect transistor gated by structure-switching aptamer probes, Talanta, 2022, 237: 122965.(封面論文,featured article)
4.Yuhong Wang, Yulong Bi, Rongrong Wang, Lu Wang, Hao Qu*, and Lei Zheng, DNA-Gated Graphene Field-Effect Transistors for Specific Detection of Arsenic(III) in Rice, Journal of Agricultural and Food Chemistry, 2021, 69(4): 1398–1404.(封面論文)
5.Rongrong Wang, Yuhong Wang, Hao Qu*, Lei Zheng*, An Acetylcholinesterase-Functionalized Biosensor for Sensitive Detection of Organophosphorus Pesticides Based on Solution-Gated Graphene Transistors, ACS Agricultural Science & Technology, 2021, 1, 372–378.
6.Rongrong Wang, Yu Mao, Lu Wang, Hao Qu*, Ying Chen, Lei Zheng*, Solution-gated graphene transistor based sensor for histamine detection with gold nanoparticles decorated graphene and multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2021, 347: 128980.
7.Yu Mao, Shengjie Gao, Lili Yao, Lu Wang, Hao Qu*, Yuen Wu, Ying Chen, Lei Zheng*, Single-atom nanozyme enabled fast and highly sensitive colorimetric detection of Cr(VI), Journal of Hazardous Materials, 2021, 408: 124898.
8.Shengjie Gao, Rongrong Wang, Yulong Bi, Hao Qu*, Ying Chen, Lei Zheng*, Identification of frozen/thawed beef based on label-free detection of hemin (Iron Porphyrin) with solution-gated graphene transistor sensors, Sensors & Actuators: B. Chemical, 2020, 305: 127167.
9.Yulong Bi, Lihui Ye, Yu Mao, Lu Wang*, Hao Qu*, Jian Liu*, Lei Zheng*. Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for ultrasensitive and real-time detection of lactic acid from cancer cell metabolism, Biosensors & Bioelectronics, 2019, 140: 111271.
10.Rongrong Wang, Yu Mao, Hao Qu*, Wei Chen, Aijin Ma, Lei Zheng*, Highly sensitive and selective sulfite sensors based on solution-gated graphene transistors with multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2019, 290: 101-106.
11.Can Xiong, Tengfei Zhang, Di Wang, Yi Lin, Hao Qu*, Wei Chen, Linbao Luo, Yanbo Wang, Lei Zheng*, Linglin Fu*, Highly sensitive solution-gated graphene transistor based sensor for continuous and real-time detection of free chlorine, Analytica Chimica Acta, 2018, 1033: 65-72.
12.Can Xiong, Tengfei Zhang, Weiyu Kong, Zhixiang Zhang, Hao Qu*, Wei Chen, Yanbo Wang, Linbao Luo, Lei Zheng*, ZIF-67 derived porous Co3O4 hollow nanopolyhedron functionalized solution-gated graphene transistors for simultaneous detection of glucose and uric acid in tears, Biosensors & Bioelectronics, 2018, 101: 21-28.
13.Can Xiong#, Yang Wang#, Hao Qu*, Lijun Zhang, Longzhen Qiu, Wei Chen, Feng Yan, and Lei Zheng*, Highly sensitive detection of gallic acid based on organic electrochemical transistors with poly(diallyldimethylammonium chloride) and carbon nanomaterials nanocomposites functionalized gate electrodes, Sensors & Actuators: B. Chemical, 2017, 246: 235-242.
14.Can Xiong, Hao Qu*, Wei Chen, Lijun Zhang, Longzhen Qiu, Lei Zheng*, Fan Xia, Real-time detection of Cu(II) with PEDOT:PSS based organic electrochemical transistors, Science China Chemistry, 2017, 60(9): 1205–1211.
發(fā)明專利
1、一種快速檢測牛肉凍融程度的方法,專利授權(quán)號:ZL201811643087.9.(第二發(fā)明人);
2、一種基于層狀碳納米片的酒精水凝膠傳感設備及其方法,專利授權(quán)號:ZL202110052279.8(第二發(fā)明人)。
參編標準
1、國家標準,《核酸適配體體外篩選技術導則》,GB/T 38137-2019,2019-10-18發(fā)布實施;
2、國家標準,《核酸適配體親和性和特異性評價技術導則》,GB/T 40187-2021,2021-05-21發(fā)布,2021-12-01實施。